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KMID : 0605720010070010081
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Journal of the Korean Society of Biological Therapies in Psychiatry
2001 Volume.7 No. 1 p.81 ~ p.86
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Effects of Olanzapine on Cognitive Functions in Schizophrenic Patients
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강병조/Byung Jo Kang
김양태/김문두*/이승재/박영우†/Yang Tae Kim/Moon Doo Kim/Seung Jae Lee*/Young Woo Park†
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Abstract
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Objects: The purpose of this study was to test the effects of olanzapine on cognitive function in schizophrenic patients.
Methods: The subjects were 16 haloperidol-medicated schizophrenic patients and 15 risperidone-medicated schizophrenic patients, who participated in an eight-week crossover study from haloperidol and risperidone to olanzapine.
Results: The patients in the group of crossover from haloperidol to olanzapin showed significant improvement in Parkinson scale of ESRS and other cognitive functions except for verbal fluency. Negative scale of PANSS and cognitive funcions such
as
verbal memory, verbal fluency, visual memory and executive function were significantly improved in patients in the group of crossover from risperidone to olanzapine.
Conclusions: These data suggest that olanzapin has some superior cognitive benefits relative to haloperidol and risperidone, but a larger sample replication study is necessary.
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